logo-horizontal-color Created with Sketch.

Sansbury BM, Wagner AM, Tarcic G, Nitzan E, Barth S, Goldfus R, Vidne M, Kmiec EB (2019) CRISPR-directed gene editing catalyzes precise gene segment replacement in vitro enabling a novel method for multiplex site-directed mutagenesis. CRISPR Journal, Vol. 2, No.2 (doi.org/10.1089/cirspr.2018.0054).

Kmiec EB (2019) CRISPR-Directed Gene Editing in a Community Cancer Center, Oncology Issues, 34:1, 31-37, (DOI: 10.1080/10463356.2018.1553424).

Bialk P, Wang Y, Banas K, Kmiec EB (2018) Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model, Molecular Therapy – Oncolytics. (DOI: 10.1016/j.omto.2018.10.002).

Modarai SR, Man D, Bialk P, Rivera-Torres N, Bloh K, Kmiec EB (2018) Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex, Molecular Therapy – Nucleic Acids. (DOI: 10.1016/j.omtn.2018.01.013).

Rivera-Torres N, Kmiec EB (2017) A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells, Journal of Visualized Experiments. (DOI: 10.3791/56195).

Bloh K, Bialk P, Gopalakrishnapillai A, Kolb EA, Kmiec EB (2017) Allelic analysis of on-target CRISPR/Cas9 heterogeneity by the focused disruption and reassignment of the GATA1 initiation codon in ML-DS, Molecular Therapy – Nucleic Acids. (DOI: 10.1016/j.omtn.2017.04.009).

Woolf TM, Channabasavaiah GB, Boyce F, Kmiec EB (2017) To Cleave or Not to Cleave:  Therapeutic Editing with and without Programmable Nucleases. Nature, Drug Development (doi:10.1038/nrd.2017.42).

Rivera-Torres N, Banas K, Bialk PB, Bloh K, Kmiec EB (2017) Insertional mutagenesis by CRISPR/Cas9 Ribonucleoprotein gene editing in cells targeted for point mutation repair directed by short single-stranded DNA oligonucleotides.  PLOS ONE (http://dx.doi.org/10.1371/journal.pone.0169350).

McDougald DS, Kmiec EB, Mills JA (2016) Personalized models reveal mechanistic and therapeutic insights into CEP290-associated Leber congenital amaurosis. Stem Cell (doi: 10.21037/sci.2016.10.03).

>Kmiec EB (2016) Gene Editing for Cancer is Coming of Age. Oncology Times (doi: 10.1097/01.COT.0000502644.42641.e4).

Bialk P, Sansbury B, Rivera-Torres N, Bloh K, Dula M, Kmiec EB (2016) Analysis of point mutation repair and allelic heterogeneity generated by CRISP/Cas9 and single-stranded DNA oligonucleotides. Nature: Sci. Rep. (doi:10. 1038/srep32681).

Rivera-Torres N, Kmiec EB (2015) Genetic spellchecking: gene editing using single-stranded DNA oligonucleotides. Plant Biotech Journal (doi.10.1111-1-8).

Bialk, P., Rivera-Torres, N., Strouse, B., & Kmiec, E. B. (2015). Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. PLoS ONE, 10(6), e0129308.

Kmiec EB (2015) Is the age of genetic surgery finally upon us? Surgical Oncology 24:95-99.

Strouse B, Bialk P, Niamat R, Rivera-Torres N and Kmiec EB (2014) Combinatorial gene editing in mammalian cells using ssODNs and TALENs. Nature; Sci. Rep. 4:379, 1-9.

Rivera-Torres N, Strouse B, Bialk P, Niamat R and Kmiec EB (2014) Strand bias and proximal cleavage by TALENs influence the frequency of gene editing directed by ssODNs. PLOS-ONE 9:5, e96483.

Borjigin M, Strouse B, Niamat R, Bialk P, Eskridge C, Xie J and Kmiec EB (2012) Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds. Mol Ther Nucleic Acids Dec 4; 1:e59.

Bonner M, Livingston P, Applegate M and Kmiec EB (2012). DNA Damage Response and Replication Fork Stress During Oligonucleotide Directed Gene Editing Molecular Therapy 1, e18: 3 April, 2012 (1-14).

Engstrom J and Kmiec EB (2008) DNA Replication, Cell Cycle Progression and the Targeted Gene Repair Reaction. Cell Cycle Feb 28;7(10).

Ferrara L and Kmiec EB (2006) Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells. DNA Repair (Amst). 2006 Apr 8;5(4):422-31. Epub 2006 Jan 18.

Brachman E and Kmiec EB (2005) Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks. DNA Repair 4, 445-457.

Ferrara F and Kmiec EB (2004) Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination. Nucleic Acids Research. 32(17), 5239-5248.

Brachman E and Kmiec EB (2003) Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides. Genetics 163, 2, 527-538.

Liu L, Parekh-Olmedo H and Kmiec EB (2003) Development and regulation of gene repair. Nature Reviews Genetics 4, 679-689.