{"id":6650,"date":"2015-01-01T00:00:00","date_gmt":"2015-01-01T05:00:00","guid":{"rendered":"http:\/\/news.christianacare.org\/2015\/01\/prolonged-early-antibiotic-use-and-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants\/"},"modified":"2015-01-01T00:00:00","modified_gmt":"2015-01-01T05:00:00","slug":"prolonged-early-antibiotic-use-and-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants","status":"publish","type":"post","link":"https:\/\/research.christianacare.org\/publications\/2015\/01\/01\/prolonged-early-antibiotic-use-and-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants\/","title":{"rendered":"Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants"},"content":{"rendered":"<p>Novitsky A, Tuttle D, Locke RG, Saiman L, Mackley A, Paul DA<\/p>\n<p>Am J Perinatol 2015 Jan;32(1):43-8<\/p>\n<p>PMID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24792766\" target=\"_blank\">24792766<\/a><\/p>\n<h2>Abstract<\/h2>\n<p><p><strong>OBJECTIVE: <\/strong>The objective of the article is to determine if\u2009&gt;\u200948 hours of antibiotic treatment during the 1st week of life is associated with subsequent isolation of bacteria from the endotracheal tube (ETT), and an increased risk of bronchopulmonary dysplasia (BPD).<\/p>\n<p><strong>STUDY DESIGN: <\/strong>Retrospective cohort study of very low birth weight infants. Routine weekly surveillance ETT cultures were obtained to monitor bacterial colonization in all intubated infants. Risk factors for BPD were assessed using unadjusted and multivariable analyses.<\/p>\n<p><strong>RESULTS: <\/strong>In the study sample (n\u2009=\u2009906), infants with BPD (n\u2009=\u2009182) were more likely to have received\u2009&gt;\u200948 hours antibiotic treatment (31 vs. 14%, p\u2009\u200948 hours of antibiotics remained associated with BPD (adjusted odds ratio, 2.2; 95% confidence interval, 1.4-3.5) after controlling for confounding variables.<\/p>\n<p><strong>CONCLUSIONS: <\/strong>Antibiotic duration\u2009&gt;\u200948 hours in the 1st week of life was associated with subsequent BPD and the presence of resistant bacteria in routine ETT cultures.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Novitsky A, Tuttle D, Locke RG, Saiman L, Mackley A, Paul DA Am J Perinatol 2015 Jan;32(1):43-8 PMID: 24792766 Abstract OBJECTIVE: The objective of the article is to determine if\u2009&gt;\u200948 hours of antibiotic treatment during the 1st week of life is associated with subsequent isolation of bacteria from the endotracheal tube (ETT), and an increased<\/p>\n<p><a class=\"more-link\" href=\"https:\/\/research.christianacare.org\/publications\/2015\/01\/01\/prolonged-early-antibiotic-use-and-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants\/\">Continue reading <span class=\"screen-reader-text\">Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6650","post","type-post","status-publish","format-standard","hentry","category-pubs-pres"],"acf":[],"_links":{"self":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts\/6650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/comments?post=6650"}],"version-history":[{"count":0,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts\/6650\/revisions"}],"wp:attachment":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/media?parent=6650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/categories?post=6650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/tags?post=6650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}