{"id":6675,"date":"2014-12-01T00:00:00","date_gmt":"2014-12-01T05:00:00","guid":{"rendered":"http:\/\/news.christianacare.org\/2014\/12\/meta-analysis-of-three-randomized-controlled-trials-comparing-coronary-artery-bypass-grafting-with-percutaneous-coronary-intervention-using-drug-eluting-stenting-in-patients-with-diabetes\/"},"modified":"2014-12-01T00:00:00","modified_gmt":"2014-12-01T05:00:00","slug":"meta-analysis-of-three-randomized-controlled-trials-comparing-coronary-artery-bypass-grafting-with-percutaneous-coronary-intervention-using-drug-eluting-stenting-in-patients-with-diabetes","status":"publish","type":"post","link":"https:\/\/research.christianacare.org\/publications\/2014\/12\/01\/meta-analysis-of-three-randomized-controlled-trials-comparing-coronary-artery-bypass-grafting-with-percutaneous-coronary-intervention-using-drug-eluting-stenting-in-patients-with-diabetes\/","title":{"rendered":"Meta-analysis of three randomized controlled trials comparing coronary artery bypass grafting with percutaneous coronary intervention using drug-eluting stenting in patients with diabetes"},"content":{"rendered":"<p>Fanari Z, Weiss SA, Zhang W, Sonnad SS, Weintraub WS<\/p>\n<p>Interact Cardiovasc Thorac Surg 2014 Dec;19(6):1002-7<\/p>\n<p>PMID: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25185569\" target=\"_blank\">25185569<\/a><\/p>\n<h2>Abstract<\/h2>\n<p><p><strong>OBJECTIVES: <\/strong>Coronary artery bypass grafting (CABG) was found to be the preferred strategy of revascularization in patients with diabetes in the bare-metal stent (BMS) era. The introduction of drug-eluting stents (DESs) led to a significant reduction in the rates of repeat revascularization (RRV) when compared with BMSs. We did a collaborative analysis of data from randomized controlled trials in the contemporary era to compare CABG versus percutaneous coronary intervention using DESs in diabetic patients.<\/p>\n<p><strong>METHODS: <\/strong>We performed a systematic review and meta-analysis from randomized trials in the contemporary era comparing PCI with DESs with CABG in diabetic patients with multivessel disease. A comprehensive literature search (1 January 2003 to 18 May 2013) identified randomized controlled trials that reported long-term outcomes comparing PCI using DESs with CABG in 2974 diabetic patients.<\/p>\n<p><strong>RESULTS: <\/strong>At 1 year, PCI was associated with a significant increase in the incidence of RRV [2.48 (1.56-3.94); P \u22640.0001], lower incidence of stroke [relative risk (RR) = 0.43 (0.19-0.81); P = 0.017], and no difference in death or myocardial infarction (MI). At 5 years, PCI was still associated with a lower incidence of stroke, but was associated with a significant increase in the incidence of death [RR = 1.36 (1.11-1.66); P = 0.0033] and MI [RR = 2.01 (1.54-2.62); P \u22640.0001].<\/p>\n<p><strong>CONCLUSIONS: <\/strong>In patients with diabetes, PCI was associated with no difference in death and MI at 1 year. However, at 5 years, PCI was associated with a higher incidence of death and MI. PCI was associated with a higher incidence of RRV but a lower incidence of stroke.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fanari Z, Weiss SA, Zhang W, Sonnad SS, Weintraub WS Interact Cardiovasc Thorac Surg 2014 Dec;19(6):1002-7 PMID: 25185569 Abstract OBJECTIVES: Coronary artery bypass grafting (CABG) was found to be the preferred strategy of revascularization in patients with diabetes in the bare-metal stent (BMS) era. The introduction of drug-eluting stents (DESs) led to a significant reduction<\/p>\n<p><a class=\"more-link\" href=\"https:\/\/research.christianacare.org\/publications\/2014\/12\/01\/meta-analysis-of-three-randomized-controlled-trials-comparing-coronary-artery-bypass-grafting-with-percutaneous-coronary-intervention-using-drug-eluting-stenting-in-patients-with-diabetes\/\">Continue reading <span class=\"screen-reader-text\">Meta-analysis of three randomized controlled trials comparing coronary artery bypass grafting with percutaneous coronary intervention using drug-eluting stenting in patients with diabetes<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6675","post","type-post","status-publish","format-standard","hentry","category-pubs-pres"],"acf":[],"_links":{"self":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts\/6675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/comments?post=6675"}],"version-history":[{"count":0,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/posts\/6675\/revisions"}],"wp:attachment":[{"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/media?parent=6675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/categories?post=6675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.christianacare.org\/publications\/wp-json\/wp\/v2\/tags?post=6675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}