Endothelial Function in Relatively Healthy Persons: Studies of the Old Order Amish

Endothelial cells are the first layer response to atherosclerotic risk factors. In clinically healthy individuals with no overt disease, Laser Doppler Flowmetry is used to evaluate endothelial function. This presentation will review endothelial cell response to clopidogrel and clopidogrels activation in the body. Last, we will review genetic determinants of endothelial growth factor angiopoietin-2, a putative biomarker in vasculature-related disease.

Dr. Salimi is an epidemiologist/physician completing her fellowship at the University of Maryland. She has experience in international research and public health implementation and has worked with research design and implementation. Her fellowship has centered on genetic epidemiology and the epidemiology of aging, focusing on genetic determinants of biomarkers and inflammatory states in relation to chronic conditions in older adults. Her research activity has focused on endothelial function in healthy individuals to understand early risk factors for developing atherosclerosis and her interests relate to genomics research.

The Innovative Discoveries Series, sponsored by the Delaware Clinical & Translational Science ACCEL program and the Christiana Care Value Institute, features informal presentations on topics relevant to current research and healthcare practice, led by knowledgeable and experienced presenters. There are offerings for researchers, healthcare providers, and community members of varying levels of experience.

These free talks are held Fridays at noon at Christiana Hospital but can be viewed from your home or office computer. Earn CMEs by participating in-person or online. Lunch is served and all are welcome to attend.

To see the full calendar of events, visit the Value Institute Events page or the ACCEL website, or subscribe to the ID Series mailing list.

Contact Sarahfaye Dolman at sarahfaye.f.dolman@christianacare.org with any questions.


  • Shabnam Salimi, MD, MSc