Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL Laryngoscope 2014 Feb;124(2):456-61 PMID: 23832678 Abstract OBJECTIVES/HYPOTHESIS: To create a novel model for development of a tissue-engineered salivary gland from human salivary gland cells that retains progenitor cell markers useful for treatment of radiation-induced xerostomia. STUDY DESIGN: A three-dimensional (3D) hyaluronic acid (HA)-based
Category: Cancer
Combined KIT and FGFR2b Signaling Regulates Epithelial Progenitor Expansion during Organogenesis
Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP Stem Cell Reports 2013;1(6):604-19 PMID: 24371813 Abstract Organ formation and regeneration require epithelial progenitor expansion to engineer, maintain, and repair the branched tissue architecture. Identifying the mechanisms that control progenitor expansion will inform therapeutic organ (re)generation. Here, we discover that combined