Category: Topics

Single Molecule DNA and RNA Sequencing to Detect Residual Cancer and Clonal Hematopoiesis

Innovative Discoveries Series Dr. Todd Druley will discuss novel strategies for single molecule DNA and RNA sequencing as a modality for characterization of clonal hematopoiesis and minimal residual disease (MRD) detection in cancer. Despite “deep sequencing,” next-generation platforms have an error rate of 0.5-1.0%, precluding straightforward sequencing for MRD, which requires sensitivity of <1:1,000. However, […]

Mixed-Methods with Teens: A Research Imperative

Innovative Discoveries Series Mixed-methods research and adolescent males aren’t often paired in the same sentence. However, they could – and should – be! Join Dr. Judith Herrman and Katie Haigh from the University of Delaware and Christopher Moore from the Department of Family and Community Medicine as they present their research evaluating the impact of […]

Partners in Research Town Hall: Confidentiality and Safety of Data

Open Forum Learning Sessions All meetings are at the John H. Ammon Medical Education Center – Room 14, at Christiana Hospital from 5:00 – 6:00 p.m. If you cannot attend, meetings are also broadcast via the bluejeans website at the appointed meeting time. For more information, or to register, please visit: Delaware CKD Engagment Project. […]

Delaware CTR-ACCEL Community Research Exchange

Our invited guest speakers are part of a team who won the 2014 Team Science Award from the Association for Clinical and Translational Science: Bowen Chung, MD, MSHS, is an Associate Professor-in-Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA, an Adjunct Scientist at the RAND […]

Optimizing Value through Appropriate Use of Invasive Cardiovascular Services

The perceived role of invasive cardiac services, especially percutaneous transluminal interventions (PCI), has changed significantly over the past 5-10 years. New healthcare payment models will apply new pressures to assure that only procedures of high value are performed. I will review changes in the use of, and perceptions about, invasive cardiac services over the past […]

Constrained Randomization: Applications to Group Randomized Trials

This seminar will include a discussion about different types of randomization strategies, focusing on applications to group randomized trials. Novel randomization strategies will be outlined, along with pros and cons of each. The use of one of these new strategies in the context of an intervention to improve colorectal cancer screening will be highlighted. Dr. […]

New Strategies to Identify Genes Linked to Human Birth Defects

This presentation will introduce an integrated approach to identify genes linked to human structural birth defects. Specifically, the application of systems based approaches in combination with animal models to identify the genetic basis of ocular and craniofacial defects will be discussed. Dr. Lachke is an Assistant Professor at the University of Delaware’s Department of Biological […]

Innovative Strategies for Engaging Vulnerable Populations

The purpose of this talk is to describe effective academic-community partnerships to engage vulnerable populations. The talk will draw evidence and lessons from two major efforts. The first was a long-term project on youth homelessness, conducted in partnership with arts-based organizations, social service providers, journalists, researchers, and marginalized youth. The second is a partnership between […]

Grouping Growth Trajectories Leading to Early Childhood Obesity: An Application of Mixed Effects Model

This seminar will present an innovative use of the mixed effects model in grouping children with distinct trajectories leading to early childhood obesity. The heterogeneity in the subject-specific effects of the mixed effects model was used to classify 488 children with differential pathways to early childhood obesity. Further investigation was performed to explore the association […]

Owning Attention: Applying Human Factors to Alert Design

Alert numbness and fatigue is a blight on the health care industry. Because we can alert on basically anything, and we can argue that anything could be a harbinger of things that could drastically affect care, we generally put an alert on everything we get our hands on. This presentation will explain the impact on […]