Category: Research, Design, and Statistics

P-Values in Modern Research

This talk will cover p-values and their role in modern research, including a brief discussion of their short comings and impact on publication literature. Also covered will be a few ways that researchers should be aware of for manipulating p-values, and how to avoid making these (sometimes inadvertent) errors. Dr. Pohlig is the Biostatistician for […]

The Human Gut Microbiome and Health: Insights from System-Level Models

There has been a revolution in medical thinking based on the large number of diseases that have been associated with alterations in the composition of the human microbiome. Examples include autism, allergies, Inflammatory Bowel Diseases (IBD), diabetes, obesity, cardiovascular diseases, autoimmune diseases, and neurological disorders such as Autism Spectrum Disorders (ASD). A major research challenge […]

Tips on Designing and Using REDCap Projects

REDCap (Research Electronic Data Capture) is a secure web application for data management. This web application allows users to build and manage online surveys and databases for a variety of purposes including basic, clinical, translational and behavioral research, repositories and operational support. The DE-CTR (ACCEL), Nemours, Christiana Care Health Services, the University of Delaware and […]

Evidence Generation using the OMOP Common Data Model

“If you want to find out how Big Data is helping to make the world a better place, there’s no better example than the uses being found for it in healthcare.” Bernard Marr, Forbes, April 21, 2015 Dr. Reich is Principal Investigator for OHDSI, a multi-stakeholder research collaborative bringing out the value of health data […]

Introduction to Structural Equation Modeling

Structural equation modeling (SEM) is one of the most powerful techniques for analyzing data based on theory. This presentation will introduce and conceptually explain SEM and allow clinicians and researchers to understand the methodologies used in publications and better synthesize results across studies. Dr. Pohlig is the Biostatistician for the University of Delaware’s College of […]

Composite Outcomes vs. Multistate Competing Risks

The primary outcome of most cardiovascular studies is a composite of several major events such as cardiovascular death, death from any cause, non-fatal MI or stroke. A patient is considered to experience a “cardiovascular event” if at least one of these outcomes occurs. Often, analyses are subsequently made of each event separately. This talk presents […]

Disparities in Obesity among US Adolescents with Disabilities

Childhood obesity is a major public health concern. Children with a broad range of disabilities have a higher prevalence of obesity. This presentation will examine disparities in obesity rates by disability status among a US sample of adolescents aged 12 to 18 years. Key risk factors for obesity among adolescents with disabilities will be identified […]

Social and Spatial Correlates of Infection in the Neonatal ICU

Traditionally risk factors for neonatal infection in the ICU are related to characteristics of the baby (or mom). But, there may be other extrinsic factors at play, such as the provider team (who takes care of which babies) and location within the unit (environmental factors). Infectious disease epidemiology focuses on risk being related to a […]

Can Big Data be Used for Comparative Effectiveness Research?

Data sets in medicine and health care are becoming larger and considerably more complex, meeting the definition of Big Data. The idea has been advanced that such data can be used to compare forms of therapy and inform medical decision making. While this is at times possible, there are considerable challenges in doing so. This […]

An Introduction to Comparative Effectiveness

Dr. Weintraub is Principal Investigator for the DE-CTR Accel Program at Christiana, and Director of the Clinical Research Design, Epidemiology, and Biostatistics Core. He is Professor of Medicine at Thomas Jefferson University and Adjunct Professor of Health Sciences at the University of Delaware. He received his MD from Johns Hopkins in 1975 and trained at […]