Weight status and perception of colorectal cancer risk

Bittner Fagan H, Sifri R, Wender R, Schumacher E, Reed JF J Am Board Fam Med 2012 Nov-Dec;25(6):792-7 PMID: 23136317 Abstract BACKGROUND: Obesity increases the risk of many cancers including colorectal cancer (CRC). METHODS: This is secondary data analysis of the 2010 National Health Interview Survey data. A total of 9360 obese and overweight participants,

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Quality of breast cancer care: perception versus practice

Bickell NA, Neuman J, Fei K, Franco R, Joseph KA J. Clin. Oncol. 2012 May;30(15):1791-5 PMID: 22493417 Abstract PURPOSE: Because insurers use performance and quality metrics to inform reimbursement, identifying remediable causes of poor-quality cancer care is imperative. We undertook this descriptive cohort study to assess key predictors of women’s perceived quality of their breast

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DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing

Bonner M, Strouse B, Applegate M, Livingston P, Kmiec EB Mol Ther Nucleic Acids 2012 Apr;1:e18 PMID: 23343929 Abstract Single-stranded DNA oligonucleotides (ODNs) can be used to direct the exchange of nucleotides in the genome of mammalian cells in a process known as gene editing. Once refined, gene editing should become a viable option for

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Trauma leadership: does perception drive reality?

Sakran JV, Finneman B, Maxwell C, Sonnad SS, Sarani B, Pascual J, Kim P, Schwab CW, Sims C J Surg Educ 2012 Mar-Apr;69(2):236-40 PMID: 22365872 Abstract INTRODUCTION: Leadership plays a key role in trauma team management and might affect the efficiency of patient care. Our hypothesis was that a positive relationship exists between the trauma

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Extended trimethoprim/sulfamethoxazole prophylaxis for implant reconstruction in the previously irradiated chest wall

Mirzabeigi MN, Lee M, Smartt JM, Jandali S, Sonnad SS, Serletti JM Plast. Reconstr. Surg. 2012 Jan;129(1):37e-45e PMID: 22186583 Abstract BACKGROUND: Patients who have undergone prior chest wall irradiation can present as challenging candidates for implant reconstruction because of troublesome rates of infectious complications. The issue of antibiotic prophylaxis remains controversial, and evidence-based postoperative strategies

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Prevalence of financial conflicts of interest among panel members producing clinical practice guidelines in Canada and United States: cross sectional study

Neuman J, Korenstein D, Ross JS, Keyhani S BMJ 2011 Oct;343:d5621 PMID: 21990257 Abstract OBJECTIVE: To determine the prevalence of financial conflicts of interest among members of panels producing clinical practice guidelines on screening, treatment, or both for hyperlipidaemia or diabetes. DESIGN: Cross sectional study. SETTING: Relevant guidelines published by national organisations in the United

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A writing group for female assistant professors

Sonnad SS, Goldsack J, McGowan KL J Natl Med Assoc 2011 Sep-Oct;103(9-10):811-5 PMID: 22364047 Abstract INTRODUCTION: The number of female medical school faculty being promoted and the speed at which they are promoted have not kept pace with their male counterparts at many institutions. One of the reasons is that these women are not publishing

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Systemic barriers to diabetes management in primary care: a qualitative analysis of Delaware physicians

Elliott DJ, Robinson EJ, Sanford M, Herrman JW, Riesenberg LA Am J Med Qual 2011 Jul-Aug;26(4):284-90 PMID: 21393616 Abstract Primary care providers deliver the majority of care for patients with diabetes. This article presents a qualitative analysis of systemic barriers to primary care diabetes management in the small office setting in Delaware. Grounded theory was

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Improved survival after pulmonary metastasectomy for soft tissue sarcoma

Predina JD, Puc MM, Bergey MR, Sonnad SS, Kucharczuk JC, Staddon A, Kaiser LR, Shrager JB J Thorac Oncol 2011 May;6(5):913-9 PMID: 21750417 Abstract INTRODUCTION: Survival after pulmonary metastasectomy for soft tissue sarcoma (STS) has been lower than in osteosarcoma (14-40% versus 40-50%). With improved patient selection criteria and advanced chemotherapy agents, we hypothesized that

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Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides

Falgowski K, Falgowski C, York-Vickers C, Kmiec EB Nucleic Acids Res. 2011 Jun;39(11):4783-94 PMID: 21343181 Abstract Gene editing directed by modified single-stranded DNA oligonucleotides has been used to alter a single base pair in a variety of biological systems. It is likely that gene editing is facilitated by the direct incorporation of the oligonucleotides via

Continue reading Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides